Steroid sulfatase-IN-1

CAS: 2403716-19-6 F: C14H10Cl2N4O3S W: 385.23

Steroid sulfatase-IN-1 is a potent and orally active Steroid sulfatase inhibitor with an IC50 of 1.71 µM. Steroid sulfa

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Bioactivity	Steroid sulfatase-IN-1 is a potent and orally active Steroid sulfatase inhibitor with an IC50 of 1.71 µM. Steroid sulfatase-IN-1 shows antitumor activity (TGI=51%) in vivo. Steroid sulfatase-IN-1 has the potential for the research of breast cancer[1].
Target	IC50: 1.71 µM (Steroid sulfatase)
In Vivo	Steroid sulfatase-IN-1 (compound 4 b) (50 mg/kg; p.o.) shows significant antitumor activity with the TGI value of 51%[1]. Animal Model:
Name	Steroid sulfatase-IN-1
CAS	2403716-19-6
Formula	C14H10Cl2N4O3S
Molar Mass	385.23
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Biernacki K, et al. Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer. J Med Chem. 2022; 65(6):5044-5056.

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