| Bioactivity | Stalk peptide is a GPR110 activator. Stalk peptide is released from GPCR Autoproteolysis INducing domain by autocatalytic process and then Stalk peptide is inserted into the ligand-binding pocket of the receptor to activate the receptor. Stalk peptide can promote nerve growth and synaptic formation. Stalk peptide can be used to study neurodevelopmental and neurodegenerative diseases[1]. |
| Sequence | Thr-Ser-Phe-Ser-Ile-Leu-Met-Ser-Pro-Asn |
| Shortening | TSFSILMSPN |
| Formula | C48H77N11O16S |
| Molar Mass | 1096.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhu X, et al. Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling[J]. Nature Communications, 2022, 13(1): 5513. |