| Bioactivity | Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 exhibits poor cell permeability[1]. | ||||||||||||
| Target | IC50: 82 nM (STAT5b) | ||||||||||||
| Invitro | Stafib-2 has an extremely high affinity for STAT5b (Ki=8.8 nM)[1].Stafib-2 (3-10 μM; 4-48 h) does not show significant activity in K562 and MDA-MB-231 cells[1]. | ||||||||||||
| Name | Stafib-2 | ||||||||||||
| CAS | 2097938-74-2 | ||||||||||||
| Formula | C28H26N2O12P2 | ||||||||||||
| Molar Mass | 644.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Elumalai N, et, al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7(1):819. |
Stafib-2
CAS: 2097938-74-2 F: C28H26N2O12P2 W: 644.46
Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for ST
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.