Stacofylline_product_DataBase

Bioactivity	Stacofylline (S 9977 free base; S 9977-2 free base) a xanthine derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities[1].
Invitro	Stacofylline (S 9977-2) 通过显着增加抑制性突触后电流 (IPSC) 的衰减时间常数 (Tc) 来增强胆碱能传递[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Stacofylline 相关抗体:
In Vivo	在东莨菪碱、地西泮和电惊厥休克 (ECS) 小鼠模型中，低剂量（0.0312-0.5 mg/kg；口服）Stacofylline (S 9977) 明显减轻了三种遗忘治疗引起的记忆缺陷[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	98833-92-2
Formula	C20H33N7O3
Molar Mass	419.52
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. L E Trudeau, et al. Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85. [2]. Roger D. Porsolt, et al. Potential cognition-enhancing properties of S 9977 in three moenls of amnesia in the mouse. Drug Development Research. 1992.

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