| Bioactivity | Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC50 values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride[1]. |
| Target | IC50: 3.4 nM (squalene synthase); 99 nM (cholesterol synthesis) |
| In Vivo | Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) (100 mg/kg for hamster, 10 mg/kg for marmoset; p.o.) 对仓鼠和狨猴具有降血脂功效[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C31H39ClN2O6 |
| Molar Mass | 571.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Haginoya N, et al. Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors. J Med Chem. 2024 Mar 22. |
Squalene synthase-IN-2
CAS: F: C31H39ClN2O6 W: 571.10
Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC50 values
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