Squalene synthase-IN-1_product_DataBase

Bioactivity	Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent acting through Squalene Synthase inhibition. Squalene synthase-IN-1 exhibits an outstanding antioxidant and anti-inflammatory activity. Squalene synthase-IN-1 displays a significant reduction not only of glucose but also of oxidative stress levels, while it did not cause any toxicity[1].
In Vivo	Squalene synthase-IN-1 (compound 1) (56 μmols/kg, 腹腔注射，每日2次) 具有抗高胆固醇/抗高血脂作用，可降低 TC 和 LDL 水平，并提高 HDL 水平[1]。 Animal Model:
Name	Squalene synthase-IN-1
Formula	C17H19BrN2O2S
Molar Mass	395.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Matralis AN, et al. Effect of a new squalene synthase inhibitor on an ApoE-/- mouse model of atherosclerosis. Bioorg Med Chem. 2023 Jul 15;90:117378.

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