| Bioactivity | Spilanthol is an orally active analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial and insecticidal compound.pilanthol can induce cAMP to inhibit negative regulation of urinary concentration mechanism. Spilanthol can be use as diuretic research[1][4][5]. |
| Target | Cyclic Adenosine monophosphate (cAMP) |
| Invitro | Spilanthol (50~150 μM, 24h) 对 A549 人肺上皮细胞活力无影响[3]。Spilanthol (50~150 μM, 24h) 在 A549 人肺上皮细胞系具有抗炎的作用[3]。Spilanthol (50~150 μM, 24h) 在 A549 人肺上皮细胞系中能降低 ICAM-1 基因的表达[3]。 0 --> Spilanthol 相关抗体: Cell Viability Assay[3] Cell Line: |
| In Vivo | Spilanthol ( 1-1.875 mg/kg, Ip, Once) 在醋酸导致腹部扭动和辣椒素导致舔爪雄性 ICR 小鼠模型具有镇痛的作用[2]。Spilanthol (30 mg/kg, 口服, 一天一次共4天) 在 5-氟尿嘧啶 (HY-90006) 致瑞士小鼠肠道黏膜炎模型对肠道损伤有保护作用[4]。Spilanthol (800 mg/kg, 口服, 给药一次) 在成年 C57BL/6J 雄性小鼠中具有利尿的作用[5]。 Animal Model: |
| Name | Spilanthol |
| CAS | 25394-57-4 |
| Formula | C14H23NO |
| Molar Mass | 221.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alan F, et al. Spilanthol: occurrence, extraction, chemistry and biological activities. Elsevier. 2016:128-133 [2]. Déciga-Campos M, et al. Antinociceptive effect of Heliopsis longipes extract and affinin in mice. Planta Med. 2010 May;76(7):665-70. [3]. Huang WC, et al. Spilanthol Inhibits COX-2 and ICAM-1 Expression via Suppression of NF-κB and MAPK Signaling in Interleukin-1β-Stimulated Human Lung Epithelial Cells. Inflammation. 2018 Oct;41(5):1934-1944. [4]. de Freitas-Blanco VS, et al. Spilanthol, the Principal Alkylamide from Acmella oleracea, Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice. Planta Med. 2019 Feb;85(3):203-209. [5]. [5]Gerbino A, et al.. Spilanthol from Acmella Oleracea Lowers the Intracellular Levels of cAMP Impairing NKCC2 Phosphorylation and Water Channel AQP2 Membrane Expression in Mouse Kidney. PLoS One. 2016 May 23;11(5):e0156021. |