Spicamycin_product_DataBase

Bioactivity	Spicamycin, an adenine nucleoside antibiotic with antifungal and antitumor activities. Spicamycin is also a potent inducer of differentiation of myeloid leukemia cells. Spicamycin induces apoptosis in NB4 cells via down-regulation of Bcl-2 expression and modulation of PML protein[1][2].
Invitro	Spicamycin (10-160 ng/mL; 0-5 d) 有效抑制 NB4、NKM-1 和 HL-60 细胞的增殖和活力[1]。Spicamycin (20 ng/mL, 80 ng/mL; 48 h) 诱导 NB4、HL-60 和 NKM-1 细胞凋亡[1]。Spicamycin (20 ng /mL、40 ng /mL; 36 h) 下调 NB4 细胞中 Bcl-2 的表达[1]。Spicamycin (2.5-640 ng/mL) 对酿酒酵母菌 ATCC 9763、假丝酵母菌 IFO 0396 和mentagrophytotrichophyton 的 MIC 值分别为 25μg/mL、25μg/mL 和 1.56 μg/mL[2]. Cell Viability Assay[1] Cell Line:
Name	Spicamycin
CAS	87099-85-2
Formula	C30H51N7O7
Molar Mass	621.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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