Sphingolactone-24_product_DataBase

Bioactivity	Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury[1].
Invitro	Sphingolactone-24 (50 µM; 30 min+24 h) 可抑制 LPS 诱导的 p38 MAPK 磷酸化并拮抗 LPS (HY-D1056) 的抗凋亡作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Sphingolactone-24 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	Sphingolactone-24 (1 mg/kg; i.p.; 3 and 9 h thereafter LPS) 可减轻 LPS 诱发的 ALI 的严重程度，并提高 LPS 诱发的肺损伤小鼠的存活率[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	881177-99-7
Formula	C18H29NO4
Molar Mass	323.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lin WC, et al. Inhibition of neutrophil apoptosis via sphingolipid signaling in acute lung injury. J Pharmacol Exp Ther. 2011 Oct;339(1):45-53.

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