| Bioactivity | SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2]. |
| Invitro | SphK1&2-IN-1 (化合物 40) (10 μM) 对 SphK1 和 SphK2 的抑制率分别为 14.3% 和 26.5%[1]。SphK1&2-IN-1 (化合物 W4) (1-100 μM) 具有良好的热稳定性[1]。 |
| Name | SphK1&2-IN-1 |
| CAS | 1415662-57-5 |
| Formula | C14H14N2O3S |
| Molar Mass | 290.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. [2]. Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511. |