| Bioactivity | SphK1-IN-2 is a potent, selective SphK1 inhibitor with IC50 values of 19.81 nM and ＞10 μM for SphK1 and SphK2, respectively. SphK1-IN-2 exhibits anti-proliferative activities and induces cell cycle arrest and apoptosis. SphK1-IN-2 can be used for cancer research[1]. |
| Invitro | SphK1-IN-2 (4-24 μM; 72 hours; cancer cell lines) has anti-proliferative activity on cancer cells[1].SphK1-IN-2 (10-30 μM; 48 hours; HT-29 cells and MDA-MB-231 cells) induces G0/G1 phase arrest and apoptosis in colon cancer cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | SphK1-IN-2 |
| Formula | C27H30BrNO4S |
| Molar Mass | 544.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |