Spectinomycin sulfate hydrate

CAS: 64058-48-6 F: C14H34N2O15S W: 502.49

Spectinomycin sulfate hydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and g

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Bioactivity	Spectinomycin sulfate hydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin sulfate hydrate acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin sulfate hydrate is also a noncompetitive inhibitor of td intron RNA with an Ki value of 7.2 mM[1]-[5].
Invitro	Spectinomycin sulfate hydrate 选择性抑制细胞和大肠杆菌提取物中的蛋白质合成Spectinomycin sulfate hydrate (50 μg/mL) 可快速且可逆地抑制大肠杆菌生长，并立即抑制氨基酸掺入[1]。Spectinomycin sulfate hydrate (1 μg/mL or 3 μM) 可抑制由内源性信使 RNA 或 MS-2 噬菌体 RNA 指导的多肽合成，在大肠杆菌提取物中的最大抑制率为 70-80% [1]。Spectinomycin sulfate hydrate 通过抑制结合来阻止肽基 tRNA 从 A 位易位到 P 位延伸因子 G 到核糖体[2]。Spectinomycin sulfate hydrate 与 16S rRNA 中的残基 G1064 和 01192 特异性相互作用，并可能使其失活[2]。Spectinomycin sulfate hydrate 表现出剪接抑制作用，并且依赖于 pH 变化和 Mg2+ 浓度，表明与内含子 RNA 存在静电相互作用[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Spectinomycin sulfate hydrate 相关抗体:
In Vivo	Spectinomycin sulfate hydrate (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) 对健康小鸡表现出安全性[4]。Spectinomycin sulfate hydrate (10 mg/kg; i.v.; single dose) 的主要消除途径是肾脏排泄，约 55% 以原形排泄到尿液中[5]。药代动力学分析[5]Parameter
CAS	64058-48-6
Formula	C14H34N2O15S
Molar Mass	502.49
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Davies J, et al. Inhibition of protein synthesis by spectinomycin. Science. 1965 Sep 3;149(3688):1096-8. [2]. Brink MF, et al. Spectinomycin interacts specifically with the residues G1064 and C1192 in 16S rRNA, thereby potentially freezing this molecule into an inactive conformation. Nucleic Acids Res. 1994 Feb 11;22(3):325-31. [3]. Park IK, et al. Spectinomycin inhibits the self-splicing of the group 1 intron RNA. Biochem Biophys Res Commun. 2000 Mar 16;269(2):574-9. [4]. Madhura DB, et al. Pharmacokinetic profile of spectinomycin in rats. Pharmazie. 2013 Aug;68(8):675-6. [5]. Khan EA, et al. Safety evaluation study of lincomycin and spectinomycin hydrochloride intramuscular injection in chickens. Toxicol Rep. 2022 Jan 29;9:204-209.

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