| Bioactivity | Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research[1]. | ||||||||||||
| Target | IC50: 99 nM (Human spastin) | ||||||||||||
| Invitro | Spastazoline (10 µM; 4.5 h) affects division of HeLa cells by increasing the number of HeLa cells with intercellular bridges[1]. | ||||||||||||
| Name | Spastazoline | ||||||||||||
| CAS | 2351882-11-4 | ||||||||||||
| Formula | C20H30N8 | ||||||||||||
| Molar Mass | 382.51 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb 18. |
Spastazoline
CAS: 2351882-11-4 F: C20H30N8 W: 382.51
Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spas
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