| Bioactivity | Spantide I, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation[1][2][3]. | ||||||
| Name | Spantide I | ||||||
| CAS | 91224-37-2 | ||||||
| Shortening | {D-Arg}PKPQQ-{D-Trp}-F-{D-Trp}-LL-NH2 | ||||||
| Formula | C75H108N20O13 | ||||||
| Molar Mass | 1497.79 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Spantide I
CAS: 91224-37-2 F: C75H108N20O13 W: 1497.79
Spantide I, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 a
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