Sp-8-Br-PET-cGMPS

CAS: 172806-21-2 F: C18H15BrN5O6PS W: 540.28

Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion

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Bioactivity	Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system[1].
CAS	172806-21-2
Formula	C18H15BrN5O6PS
Molar Mass	540.28
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Barnstable, Colin J., Ji-Ye Wei, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochemistry international 45.6 (2004): 875-884.