| Bioactivity | Sp-2-Cl-cAMPS is an agonist for PKA with improved membrane permeability and stability to phosphodiesterase. Sp-2-Cl-cAMPS exhibits antimalarial activity, and inhibits the proliferation of Plasmodium falciparum with an EC50 of 4 μM. Sp-2-Cl-cAMPS binds to purified P. falciparum PfPKAr (regulatory subunit of PfPKA) with a Ki of 1.3 µM[1]. |
| CAS | 124854-63-3 |
| Formula | C10H11ClN5O5PS |
| Molar Mass | 379.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lasonder E, et al., cAMP-Dependent Signaling Pathways as Potential Targets for Inhibition of Plasmodium falciparum Blood Stages. Front Microbiol. 2021 May 24;12:684005. |
Sp-2-Cl-cAMPS
CAS: 124854-63-3 F: C10H11ClN5O5PS W: 379.72
Sp-2-Cl-cAMPS is an agonist for PKA with improved membrane permeability and stability to phosphodiesterase. Sp-2-Cl-cAMP
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