Sorbitol dehydrogenase-IN-1

CAS: 300551-49-9 F: C17H25N7O W: 343.43

Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for ra

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Bioactivity	Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively[1].
Target	Sorbitol Dehydrogenase
In Vivo	Sorbitol dehydrogenase-IN-1 (compound 16) (50 µg/kg；口服) 在慢性糖尿病大鼠中表现出对坐骨神经果糖的持续抑制作用[1]。
Name	Sorbitol dehydrogenase-IN-1
CAS	300551-49-9
Formula	C17H25N7O
Molar Mass	343.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mylari BL, et al. A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem. 2002 Sep 26;45(20):4398-401.

N-Nitroso N-methyl 4-amino butyric acid-13C,d3,15N