| Bioactivity | Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM[1][2]. |
| CAS | 583840-03-3 |
| Formula | C21H16ClF3N4O4 |
| Molar Mass | 480.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li L, et al. Quantitation of sorafenib and its active metabolite sorafenib N-oxide in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 1;878(29):3033-8. [2]. Ghassabian S, et al. Sorafenib N-Oxide Is an Inhibitor of Human Hepatic CYP3A4. AAPS J. 2019 Jan 9;21(2):15. |
Sorafenib N-oxide
CAS: 583840-03-3 F: C21H16ClF3N4O4 W: 480.82
Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of micr
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