| Bioactivity | Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity[1][2]. | ||||||||||||
| Invitro | Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis[3].Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC50s are 9.21 and 19.88 μg/ml, respectively[3]. Cell Viability Assay[3] Cell Line: | ||||||||||||
| Name | Solamargine | ||||||||||||
| CAS | 20311-51-7 | ||||||||||||
| Formula | C45H73NO15 | ||||||||||||
| Molar Mass | 868.06 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Solamargine
CAS: 20311-51-7 F: C45H73NO15 W: 868.06
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous t
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