Sodium stibogluconate

CAS: 16037-91-5 F: C12H38Na3O26Sb2 W: 910.90

Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodi

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Bioactivity	Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.
Target	Phosphatase
Invitro	Sodium stibogluconate (Stibogluconate trisodium nonahydrate) 在 10 μg/mL (利什曼病药物的处理浓度) 下抑制 99% 的 SHP-1 活性。类似程度的 SHP-2 和 PTP1B 抑制需要 100 μg/mL Sodium stibogluconate。Sodium stibogluconate 对细胞 PTPases 的抑制作用是通过其快速诱导 Baf3 细胞中细胞蛋白的酪氨酸磷酸化及其增强 IL-3 诱导的 Janus 家族激酶 2/Stat5 酪氨酸磷酸化和 Baf3 细胞增殖来表明的。Sodium stibogluconate 增强了 GM-CSF 和 IFN-α 对 TF-1 细胞生长的相反作用，表明其在各种细胞因子信号转导中具有广泛的活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Sodium stibogluconate 相关抗体:
In Vivo	Sodium stibogluconate (Stibogluconate trisodium nonahydrate) 在 BALB/c 小鼠中诱导 61% 的 Renca 肿瘤生长抑制，同时肿瘤浸润性巨噬细胞增加 (2 倍)。Sodium stibogluconate 和 IL-2 的组合在抑制肿瘤生长 (91%) 和诱导肿瘤浸润 (4 倍) 方面更有效，而单独使用 IL-2 几乎没有效果[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	16037-91-5
Formula	C12H38Na3O26Sb2
Molar Mass	910.90
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pathak MK, et al. Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol. 2001 Sep 15;167(6):3391-7. [2]. Fan K et al. Sodium Stibogluconate Interacts with IL-2 in Anti-Renca Tumor Action via a T Cell-Dependent Mechanism in Connection with Induction of Tumor-Infiltrating Macrophages. J Immunol. 2005 Nov 15;175(10):7003-8.

S49076 hydrochloride

PD-1/PD-L1-IN-53