| Bioactivity | Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2]. |
| Target | Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2). |
| Name | Sodium metatungstate |
| CAS | 12141-67-2 |
| Formula | H2Na6O40W12 |
| Molar Mass | 2986.01 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7. [2]. Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8. |
Sodium metatungstate
CAS: 12141-67-2 F: H2Na6O40W12 W: 2986.01
Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) in
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