| Bioactivity | Sob-AM2 is a potent substrate targeting fatty acid amide hydrolase (FAAH) expressed in the brain (Km=1.3 μM), delivering high concentrations of Sobetirome (HY-14823) to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ)[1]. | ||||||||||||
| CAS | 2128258-47-7 | ||||||||||||
| Formula | C21H27NO3 | ||||||||||||
| Molar Mass | 341.44 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Meinig J M, et al. Targeting fatty-acid amide hydrolase with prodrugs for CNS-selective therapy[J]. ACS chemical neuroscience, 2017, 8(11): 2468-2476. |