| Bioactivity | Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation[1]. |
| Target | Kd: 3.664 nM (Smurf1) |
| Name | Smurf1-IN-A01 |
| CAS | 1007647-73-5 |
| Formula | C22H20ClF3N4O3S |
| Molar Mass | 512.93 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965. |
Smurf1-IN-A01
CAS: 1007647-73-5 F: C22H20ClF3N4O3S W: 512.93
Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664
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