Slingshot inhibitor D3_product_DataBase

Bioactivity

Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC50 value for Slingshot 1 is 3 μM and the Ki value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2[1].

Target

Ki: 3.9 μM (Slingshot 2).IC50: 3 μM (Slingshot 1)

Invitro

Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes[1].Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation[1].Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot[1]. Western Blot Analysis[1] Cell Line:

Name

Slingshot inhibitor D3

CAS

1715076-35-9

Formula

C25H19NO4S2

Molar Mass

461.55

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Li KS, et al. Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem. 2015;10(12):1980-1987.

PeptideDB

Slingshot inhibitor D3

CAS: 1715076-35-9 F: C25H19NO4S2 W: 461.55