| Bioactivity | Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor. | ||||||||||||
| Target | p38MAPK. | ||||||||||||
| Invitro | Skepinone-L (CBS3830), the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, Skepinone-L (CBS3830) is a valuable probe for chem. biol. research, and it may foster the development of a unique class of kinase inhibitors. | ||||||||||||
| Name | Skepinone-L | ||||||||||||
| CAS | 1221485-83-1 | ||||||||||||
| Formula | C24H21F2NO4 | ||||||||||||
| Molar Mass | 425.42 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Koeberle, Solveigh C.; Romir, Johannes; Fischer, Stefan et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nature Chemical Biology (2012), 8(2), 141-143. [2]. Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter et al. Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase. Journal of Medicinal |