Sivopixant

CAS: 2414285-40-6 F: C25H22ClN5O5 W: 507.93

Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopi

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Bioactivity	Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1].
In Vivo	Sivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED50=0.4 mg/kg)[1].
Name	Sivopixant
CAS	2414285-40-6
Formula	C25H22ClN5O5
Molar Mass	507.93
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kai H, et al. Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists [published online ahead of print, 2021 Sep 26]. Bioorg Med Chem Lett. 2021;52:128384.