| Bioactivity | Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity[1]. |
| Target | IC50: 1.2 μM (SIRT1), 1.9 μM (SIRT2), 18.6 μM (SIRT3) |
| Invitro | Sirt1/2-IN-4 (compound PS3) (5 μM; 48 h) 诱导不同肿瘤细胞凋亡，IC50 分别为 6.5 μM (MV4-11)、9.2μM (MOLM-13)、27.2 μM (THP1)、17.4 μM (Jurkat)[1]。 0 --> Sirt1/2-IN-4 相关抗体: |
| Name | Sirt1/2-IN-4 |
| Formula | C21H20N4O3S2 |
| Molar Mass | 440.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790. |