| Bioactivity | Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2]. | ||||||||||||
| Invitro | Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells[2]. Western Blot Analysis[2] Cell Line: | ||||||||||||
| Name | Sinefungin | ||||||||||||
| CAS | 58944-73-3 | ||||||||||||
| Formula | C15H23N7O5 | ||||||||||||
| Molar Mass | 381.39 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Sinefungin
CAS: 58944-73-3 F: C15H23N7O5 W: 381.39
Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, a
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