| Bioactivity | Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[1][2][3][4]. |
| Invitro | Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes[1].Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity[3].Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease[3].Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2[3]. |
| Name | Sinapine |
| CAS | 18696-26-9 |
| Formula | C16H24NO5 |
| Molar Mass | 310.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Sinapine
CAS: 18696-26-9 F: C16H24NO5 W: 310.36
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidan
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