| Bioactivity | Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity[1]. | ||||||||||||
| Invitro | Silvestrol aglycone (Compound 4) inhibits the proliferation of MDA-MB-231 cells with an E50 of 20 ± 10 nM after 72 h[1]. | ||||||||||||
| Name | Silvestrol aglycone | ||||||||||||
| CAS | 960365-65-5 | ||||||||||||
| Formula | C27H26O8 | ||||||||||||
| Molar Mass | 478.49 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. |
Silvestrol aglycone
CAS: 960365-65-5 F: C27H26O8 W: 478.49
Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10
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