| Bioactivity | Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 (HY-N6615), with an IC50 of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties[1][2]. |
| In Vivo | 在磷脂酶 A2 诱发的小鼠爪水肿试验中，Sigmoidin B (5 mg/kg; 腹腔注射) 在 60 分钟时抑制了水肿形成。在 Phorbol 12-myristate 13-acetate (PMA) (HY-18739) 试验中，Sigmoidin B 使诱发的水肿减少了 83%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 87746-47-2 |
| Formula | C20H20O6 |
| Molar Mass | 356.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Njamen D, et al. Anti-inflammatory activities of two flavanones, sigmoidin A and sigmoidin B, from Erythrina sigmoidea. Planta Med. 2004 Feb;70(2):104-7. [2]. Zarev Y, et al. Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima. Phytochemistry. 2017 Sep;141:140-146. |