Sigma-LIGAND-1_product_DataBase

CAS: 139652-01-0 F: C27H33NO4 W: 435.56

Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, resp

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor[1].

Target

IC50: 16 nM (DTG site of sigma receptor), 19 nM (PPP site of sigma receptor)Ki: 4000 nM (Dopamine D2 receptor)

In Vivo

Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 and its structural analogues have the potential antipsychotic activity[1].

Name

Sigma-LIGAND-1

CAS

139652-01-0

Formula

C27H33NO4

Molar Mass

435.56

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35.

PeptideDB

Sigma-LIGAND-1

CAS: 139652-01-0 F: C27H33NO4 W: 435.56