| Bioactivity | Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts[1]. |
| Target | Ki: 2.57 nM (Sigma-2, σ2) |
| Name | Sigma-2 Radioligand 1 |
| CAS | 2860554-32-9 |
| Formula | C24H30FN3O3 |
| Molar Mass | 427.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang T, et al. Development of a Highly Specific 18F-Labeled Radioligand for Imaging of the Sigma-2 Receptor in Brain Tumors. J Med Chem. 2023 Sep 13.. . |
Sigma-2 Radioligand 1
CAS: 2860554-32-9 F: C24H30FN3O3 W: 427.51
Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice
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