| Bioactivity | Sigma-1 receptor antagonist 6 (Compound 12) is an antagonist of the Sigma-1 receptor (σ1R). Sigma-1 receptor antagonist 6 exerts a robust antiallodynic effect by antagonizing σ1R. Sigma-1 receptor antagonist 6 can be administered to neuropathic animals, fully reversing the mechanical allodynia induced by paclitaxel (HY-B0015)[1]. |
| CAS | 1335032-28-4 |
| Formula | C32H34N6 |
| Molar Mass | 502.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Entrena JM, et al. The proof of concept of 2-{3-[N-(1-benzylpiperidin-4-yl)propyl]amino}-6-[N-methyl-N-(prop-2-yn-1-yl)amino]-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain. Bioorg Chem. 2024 Sep;150:107537. |
Sigma-1 receptor antagonist 6
CAS: 1335032-28-4 F: C32H34N6 W: 502.65
Sigma-1 receptor antagonist 6 (Compound 12) is an antagonist of the Sigma-1 receptor (σ1R). Sigma-1 receptor antagonist
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