| Bioactivity | Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively[1]. | ||||||||||||
| Target | Ki: 3.88 nM (σ1 receptor), 1288 nM (σ2 receptor) | ||||||||||||
| Name | Sigma-1 receptor antagonist 2 | ||||||||||||
| CAS | 1639220-15-7 | ||||||||||||
| Formula | C20H26ClN3O2 | ||||||||||||
| Molar Mass | 375.89 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23. |
Sigma-1 receptor antagonist 2
CAS: 1639220-15-7 F: C20H26ClN3O2 W: 375.89
Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM
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