| Bioactivity | Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi[1]. |
| Target | Succinate Dehydrogenase Inhibitor |
| Invitro | Siccanin (10 μg/mL) 具有物种选择性，Siccanin 抑制铜绿假单胞菌和恶臭假单胞菌的细菌 SDH，但不抑制大肠杆菌和谷氨酸棒杆菌的 SDH；Siccanin 抑制啮齿动物 SDH 但不抑制猪 SDH[1]。具体而言，Siccanin 抑制铜绿假单胞菌（残留活性 13%）和恶臭假单胞菌（>1%）膜以及小鼠（>7%）和大鼠（19%）肝线粒体的 SDH，但不抑制大肠杆菌的 SDH (77%) 和谷氨酸棒杆菌 (97%) 膜和猪心脏线粒体 (106%)[1]。Siccanin (3 μg/mL) 竞争性抑制须癣毛癣菌的生长 (IC50=0.3 μg/mL)[1]。 |
| Name | Siccanin |
| CAS | 22733-60-4 |
| Formula | C22H30O3 |
| Molar Mass | 342.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mogi T, et al. Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor. J Biochem. 2009 Sep;146(3):383-7. |