| Bioactivity | Xylocydine is a potent CDK inhibitor that specifically blocks CDK1 and CDK2/cyclin CCNA activity, while having minimal effects on other Ser/Thr protein kinases. Xylocydine potently inhibits cellular CDK1 and CDK2 activity, as evidenced by decreased levels of phosphorylated nucleolin and retinoblastoma protein. In addition, Xylocydine potently inhibits CDK function in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis, and interferes with cell cycle regulation and CDK activity in apoptotic processes associated with various diseases[1]. |
| Target | CDK1/CDK2 |
| CAS | 1346526-26-8 |
| Formula | C13H10N2O |
| Molar Mass | 210.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |