| Bioactivity | Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the FKBP mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels[1][2]. |
| CAS | 1013621-70-9 |
| Formula | C35H51N3O7 |
| Molar Mass | 625.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Grimley JS, et al. Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains. Bioorg Med Chem Lett. 2008 Jan 15;18(2):759-61. [2]. Bonger KM, et al. Small-molecule displacement of a cryptic degron causes conditional protein degradation. Nat Chem Biol. 2011 Jul 3;7(8):531-7. |
Shield-2
CAS: 1013621-70-9 F: C35H51N3O7 W: 625.80
Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Sh
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