| Bioactivity | ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1]. |
| Invitro | ShK-Dap22 suppresses T cell activation in vitro. ShK-Dap22, at subnanomolar concentrations, suppresses anti-CD3 induced human T-lymphocyte [3H]thymidine incorporation in vitro[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ShK-Dap22 相关抗体: |
| CAS | 220384-25-8 |
| Sequence | Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-{Dpr}-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (Disulfide bridge:Cys3-Cys35;Cys12-Cys28;Cys17-Cys32) |
| Shortening | RSCIDTIPKSRCTAFQCKHSM{Dpr}YRLSFCRKTCGTC (Disulfide bridge:Cys3-Cys35;Cys12-Cys28;Cys17-Cys32) |
| Formula | C166H268N54O48S7 |
| Molar Mass | 4012.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. K Kalman, et al. ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide. J Biol Chem. 1998 Dec 4;273(49):32697-707. |
ShK-Dap22
CAS: 220384-25-8 F: C166H268N54O48S7 W: 4012.69
ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with
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