| Bioactivity | Setomimycin is a potent antibiotic. Setomimycin inhibits the SARS-CoV-2 Mpro enzyme with an IC50 value of 12.02 µM. Setomimycin shows anti-inflammatory and antioxidant properties. Setomimycin shows antiproliferative and antitumor activity[1][2]. |
| Target | IC50: 12.02 µM (SARS-CoV-2 Mpro) |
| Invitro | Setomimycin (0.01-1 µM) 以剂量依赖性方式抑制细胞因子 IL-1β、IL-6 和 TNF-α 的释放以及一氧化氮的释放在 LPS 刺激的 RAW 264.7 细胞中[1]。 Setomimycin (compound 1) 显示出抗菌活性，对 Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Micrococcus luteus 的 MIC 分别为 8、4、16、4 μg/mL [2].Setomimycin (0-100 µM；5 天) 显示出抗增殖活性并抑制集落形成[2]。Setomimycin (4, 5.5, 7 µM) 降低 p-MEK、p-ERK、Bcl-2 的蛋白表达，增加 Par-4 的表达[2]。 Cell Proliferation Assay[2] Cell Line: |
| In Vivo | Setomimycin (20 mg/kg；i.p.；隔天给药两周) 在小鼠体内显示出抗肿瘤活性[2]。 Animal Model: |
| Name | Setomimycin |
| CAS | 69431-87-4 |
| Formula | C34H28O9 |
| Molar Mass | 580.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Manhas RS, et al. Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation. Mol Divers. 2023 Apr;27(2):619-633. [2]. Manhas RS, et al. Isolation and anticancer activity evaluation of rare Bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region. Chem Biol Interact. 2022 Sep 25;365:110093. |