| Bioactivity | Setileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively[1]. |
| In Vivo | Setileuton (5 mg/kg，静脉注射；20 mg/kg，口服，单剂量) 在大鼠模型中表现出良好的药代动力学特征，半衰期 T1/2 为 3.3 小时，生物利用度为 66%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 910656-27-8 |
| Formula | C22H17F4N3O4 |
| Molar Mass | 463.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ducharme Y, et al., The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor. ACS Med Chem Lett. 2010 Apr 13;1(4):170-4. |
Setileuton
CAS: 910656-27-8 F: C22H17F4N3O4 W: 463.38
Setileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant
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