| Bioactivity | Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2]. |
| Invitro | Sertraline (1 μM, 12 hours) inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor-α (TNF-α)-induced microglial activation and inflammatory mediator production in microglia[3].Sertraline (1 μM) inhibits the HMGB1/toll-like receptor 4 (TLR4)- and TNF-α/TNF receptor 1 (TNFR1)-mediated nuclear factor-kappa B (NF-κB) activation in HMGB1- or TNF-α-stimulated microglia[3]. |
| In Vivo | Sertraline (10 mg/kg) is shown to produce the optimal anti-depression effectsin chronic unpredictable mild stress (CUMS)-exposed mice[3].Sertraline (10 mg/kg; a single i.p.) significantly reduces the immobility time during forced swim test (FST) in all female animals[4].Sertraline (10 mg/kg; a single i.p.) does not alter spontaneous locomotor activity in all three genotypes regardless of sex difference[4]. Animal Model: |
| Name | Sertraline hydrochloride |
| CAS | 79559-97-0 |
| Formula | C17H18Cl3N |
| Molar Mass | 342.69 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Murdoch D, et al. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24. [2]. Koe BK. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7. [3]. Xiang X, et, al. Anti-depressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- And TNF-α/TNFR1-mediated NF-κB Activation. ACS Chem Neurosci. 2020 Jul 1. [4]. Lei M, et, al. Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models. Front Cell Neurosci. 2019 Feb 1; 13:24. |
Sertraline hydrochloride
CAS: 79559-97-0 F: C17H18Cl3N W: 342.69
Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hyd
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