| Bioactivity | Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI[1] . |
| Invitro | Ser@TPP@CUR (7.16 μg/mL; 24 h) effectively reduces ROS level in inflammatory HK-2 cells[1].Ser@TPP@CUR (3 μg/mL; 24 h) effects cell viability and inhibits expression levels of cytosolic cytochrome c, cleaved caspase-3, and cleaved caspase-9 of LPS-induced HK-2 cells[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | Ser@TPP@CUR (4 mg/kg; i.v. once) shows a better distribution in renal tissues via KIM-1-receptor-mediated endocytosis in renal tubule epithelial cells and restores renal function of AKI mice[1]. Animal Model: |
| Name | Ser@TPP@CUR |
| Formula | C47H47BrNO9P |
| Molar Mass | 880.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yan X, et al. A Stepwise Targeting Curcumin Derivative, Ser@TPP@CUR, for Acute Kidney Injury. ACS Med Chem Lett. 2022 Mar 8;13(4):554-559. |