| Bioactivity | Wu-5 is a USP10 inhibitor. Wu-5 induces the degradation of FLT3-mutated protein. Wu-5 enhances Crenolanib (HY-13223)-induced FLT3-ITD-positive AML cell death and apoptosis via inhibiting FLT3 and AMPK pathways[1]. |
| Name | Selenomethylene blue |
| CAS | 85670-01-5 |
| Formula | C16H18ClN3Se |
| Molar Mass | 366.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yu M, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612. |
Selenomethylene blue
CAS: 85670-01-5 F: C16H18ClN3Se W: 366.75
Wu-5 is a USP10 inhibitor. Wu-5 induces the degradation of FLT3-mutated protein. Wu-5 enhances Crenolanib (HY-13223)-ind
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