| Bioactivity | Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis[1][2]. |
| Invitro | Secalonic acid D (0.1-1 μM; 72 h) 在 HL60 和 K562 中以浓度依赖性方式抑制细胞增殖，IC50 分别为 0.38 μM 和 0.43 μM[1]。Secalonic acid D (0.3 μM; 12 h, 24 h) 导致细胞周期停滞在 G1 期，(1.2 μM; 0-72 h) 并诱导 HL60 和 K562 细胞凋亡[1]。 Apoptosis Analysis[1] Cell Line: |
| Name | Secalonic acid D |
| CAS | 35287-69-5 |
| Formula | C32H30O14 |
| Molar Mass | 638.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Secalonic acid D
CAS: 35287-69-5 F: C32H30O14 W: 638.57
Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Asper
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