| Bioactivity | Se2h is a cruzain inhibitor that exhibits strong activity against the intracellular amastigotes of Trypanosoma cruzi (EC50 10), with an inhibitory activity against cruzain of IC50 5.55). Compared to Benznidazole (HY-B1548) and the cruzain inhibitor K777 (HY-119293), Se2h shows superior selectivity and inhibition, while its selenazole structure reduces selenium-related toxicity. Se2h exhibits antiparasitic activity and holds promise for research in Chagas disease[1]. |
| Formula | C12H13ClN4O2Se |
| Molar Mass | 359.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rubio-Hernández M, et al. Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (S, Se) and Their Azole Derivatives against Chagas Disease. J Med Chem. 2024 Nov 14;67(21):19038-19056. |