| Bioactivity | Scalaradial is an inhibitor for bee venom phospholipase A2 (PLA2) and transient receptor potential melastatin 2 (TRPM2) ion channels, with IC50 of 0.07 and 0.21 μM. Scalaradial regulates the phosphorylation of ERK, by inhibiting secretory PLA2 and Akt. Scalaradial inhibits the PMA (HY-18739)-induced release of Arachidonic acid (HY-109590) in the mouse peritoneal macrophage[1][2][3]. |
| CAS | 53527-28-9 |
| Formula | C27H40O4 |
| Molar Mass | 428.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Starkus JG, et al., Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels. J Nat Prod. 2017 Oct 27;80(10):2741-2750. [2]. de Carvalho MS, et al., Two-step inactivation of bee venom phospholipase A2 by scalaradial. Biochem Pharmacol. 1991 Sep 27;42(8):1621-6. [3]. Xie Y, et al., Biphasic regulation of extracellular signal-regulated kinases by scalaradial, a secretory phospholipase A(2) inhibitor. Cancer Biol Ther. 2006 Aug;5(8):988-92. |