Sarecycline

CAS: 1035654-66-0 F: C24H29N3O8 W: 487.50

Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory

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Bioactivity	Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne[1][2][3][4][5][6].
Invitro	Sarecycline 抑制 55 株临床分离的痤疮棒状杆菌，其 MIC 值为 0.5~16 µg/ml; MIC50 为 0.5 µg/ml, MIC90 为 4µg/ml[1]。Sarecycline 对大环内酯耐药的生物体有活性[1]。Sarecycline hydrochloride对肠道需氧革兰氏阴性菌的活性最小[2]。 0 --> Sarecycline 相关抗体:
In Vivo	Sarecycline hydrochloride (0.33-9 mg /kg; 静脉注射) 在小鼠中性粒细胞减少的大腿感染模型中显示出对金黄色葡萄球菌的有效活性[1]。Sarecycline 在全身 (腹腔) 感染的 CD-1 小鼠模型中能够抑制金黄色葡萄糖球菌 (PD50=0.25 mg/kg)，但在最高剂量 (>40 mg/kg) 下对大肠杆菌抑制的效果不明显[6]。Sarecycline (1-150mg/kg; 腹腔注射; 单剂量) 在 Sprague Dawley 大鼠模型中具有抗炎活性[6]。 Animal Model:
Name	Sarecycline
CAS	1035654-66-0
Formula	C24H29N3O8
Molar Mass	487.50
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhanel G, et al. Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris. Antimicrob Agents Chemother. 2018 Dec 21;63(1):e01297-18. [2]. Moore AY, et al. Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris. Future Microbiol. 2019 Sep;14(14):1235-1242. [3]. Batool Z, et al. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20530-20537. [4]. Butler MS, et al. Antibiotics in the clinical pipeline in 2013. J Antibiot (Tokyo). 2013 Oct;66(10):571-91. [5]. Bunick CG, et al. Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation. Antibiotics (Basel). 2021 Apr 15;10(4):439.

Carboxypeptidase B (MS grade)