| Bioactivity | Sarecycline hydrochloride is a narrow-spectrum tetracycline-class antibiotic. Sarecycline hydrochloride possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains of Cutibacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome[1][2][3]. |
| Invitro | Sarecycline inhibits 55 clinical isolates of C. acnes, and the MIC values for Sarecycline ranged from 0.5 to 16 µg/ml; the MIC50 was 0.5 µg/ml, and the MIC90 was 4 µg/ml. Sarecycline, exhibits activity against the macrolide-resistant organisms[1].Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria[2]. |
| Name | Sarecycline hydrochloride |
| CAS | 1035979-44-2 |
| Formula | C24H30ClN3O8 |
| Molar Mass | 523.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
Sarecycline hydrochloride
CAS: 1035979-44-2 F: C24H30ClN3O8 W: 523.96
Sarecycline hydrochloride is a narrow-spectrum tetracycline-class antibiotic. Sarecycline hydrochloride possesses anti-i
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