Sarafotoxin S6d

CAS: 1446991-36-1 F: C112H163N27O34S5 W: 2591.98

Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin

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Bioactivity	Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin S6d induces multiple electrocardiogram (ECG) changes including myocardial ischemia and hyperkalemia. Sarafotoxin S6d induces strong extracellular calcium-dependent vasoconstriction in rat aorta and exhibits positive inotropic effects in rat atria. Sarafotoxin S6d can be used in the study of cardiovascular diseases[1].
In Vivo	Sarafotoxin S6d (0.3、1.0、3.0 和 5.0 nmol/kg；静脉注射) 在 0.3-3.0 nmol/kg 时可产生恒定压力效应和短暂的脉压升高。然而，在 5.0 nmol/kg 时，Sarafotoxin S6d 可在最初升高后导致血压、心率和呼吸频率迅速下降，导致大多数小鼠在 10 分钟内死亡[1]。Sarafotoxin S6d (5.0 nmol/kg；静脉注射) 可显著提高 K+ 水平 159%。此外，血浆酶 (LDH、CPK)、IP 和葡萄糖水平也显著升高。LDH 增加 60%，CPK 增加 91%，IP 增加 137%，葡萄糖增加 80%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1446991-36-1
Sequence	Cys-Thr-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Ile-Ile-Trp (disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Shortening	CTCKDMTDKECLYFCHQDIIW (disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Formula	C112H163N27O34S5
Molar Mass	2591.98
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lin W W, et al. Cardiovascular effects of two disulfide analogues of sarafotoxin S6b[J]. Toxicon, 1990, 28(8): 911-923.

Ganglioside GM1-binding peptides p3